Polikistik over sendromlu obez olmayan kadınlarda progesteron ve progesteron kaynaklı bloke edici faktör (PIBF) düzeyleri

Purpose: This study aimed to evaluate the level of progesterone and progesterone-induced blocking factor (PIBF), an immune mediator, in non-obese patients with polycystic ovary syndrome (PCOS).
 Materials Methods: Totally 72 were recruited into divided 2 groups: The first group was diagnosed PCOS (n = 36) second healthy control (n=36). diagnosis made according Rotterdam diagnostic criteria. All 18–35 years old (body mass index (BMI) < 25 kg/m2). Follicle-stimulating hormone (FSH), luteinizing (LH), estradiol (E2), thyroid-stimulating (TSH), prolactin (PRL), total testosterone, dehydroepiandrostenedione sulfate (DHEA-S) levels measured on third day menstrual cycle. On 21st same period, fasting blood glucose, insulin, progesterone, PIBF measured. 
 Results: Demographic clinical characteristics participants similar between two groups. Serum FSH, E2, TSH, PRL, DHEA-S, homeostatic model assessment for insulin resistance (HOMA-IR), hemoglobin A1c values Differences LH, LH/FSH ratio, serum statistically significant.
 Conclusion: Progesterone decreased patients. We suggest that even absence obesity, which is origin enhancer inflammation PCOS, low as underlying immunomodulator will drive complications.